Benefits and efficacy mangosteen skin is hard evidence. Many people have proved both the general public and among researchers are always trying to reveal the scientific evidence, valid, and empirical support for the belief that is true skin mangosteen has potent efficacy for treating various diseases.
Japanese researchers Contribution
French , Laurent Garcin was the inventor who first gave the name Garcinia Mangostana. It happened in the 16th century. However, Garcin only instrumental in giving the name of fruit that has now been recognized to have many benefits for human health. Until finally in 1993, Japanese, Munekazu Iiunama collect Mangosteen rind from various parts of Indonesia.
Having collected a lot, mangosteen skin are then taken to Gifu Pharmaceutical, Japan to be researched. After the mangosteen rind was in Japan, a research team consisting of Kenji Matsumoto, Munekazu Iinuma, and a few others, extract dried mangosteen skin with benzene, acetone, alcohol and 70% hexane.
Of the extraction process turns out to produce six xanthone derivatives is the main compound contained in the mangosteen fruit. Xanthone derivation consists of a-mangostin, mangostin b-, g-mangostin, mangostinone, garcinone E, 2-isoprenyl-1, 7-dihydroxy-3-methoxyxanthone.
Do not stop there, the scientists then took the cause of leukemia cells such as K562, HL60, NB4, U937 from Ibaraki, Japan. Furthermore, cancer cells that cause leukemia are then cultured.
Then, xanthone compounds from mangosteen rind is dissolved into the cell culture was the cause of leukemia. The result is quite surprising, that a-mangostin which is one element of xanthone derivatives play a role in triggering apoptotic process of leukemia cells.
This studies results seemed trigger to bring up the results of studies on the validity of the benefits Mangosteen rind .
Post-study by a team Munekazu, other studies in Switzerland found that xanthones in mangosteen rind able to cope depression.
Then around 1996, two other studies in Taiwan. Where the study found that xanthones efficacious in overcoming depression, and other studies also found that xanthones act as an anti-cancer.
In the United States, xanthones research ended at the conclusion, these compounds effective for malaria. Until finally in mid 1997-2004 research on mangosteen rind was conducted in various parts of the world and the results are very diverse: useful to cure tuberculosis, breast cancer, diabetes, and arthritis.
Antidote for present disease
Endro Nugroho Agung is one of Indonesia’s tenacious scientists in conducting research on the content and efficacy of mangosteen rind.
Findings showed that the Mangosteen skin contained at least 50 xanthones compounds that have antioxidant properties, anti-allergic, anti-tumor, anti-histamine and anti-inflammatory.
Xanthone derivatives have pharmacological effects are alpha-mangostin, beta-mangostin and garcion E. Did you know that mangostin and gamma-mangostin is able to act as an anti-oxidant that able to prevent the HIV virus activity.
While alpha-mangostin and garcinon-E plays a role in destroy cancer cells that eat away the human body. For those of you who suffer from heart disease, mangosteen skin also can help the treatment of heart disease.
Antioxidants contained in this xanthone is the highest in the world. Reached 66.7 times than the carrots, or 8.3 times that of an orange peel.
Xanthones also have hydroxide groups that reached 17.000-20.000 so it is effective to bind free radicals are capable of causing damage to body cells.
Due to have a very high xanthones antioxidant contained in mangosteen peel is helpful in increasing endurance, control hypertension, thrombosis, arthtritis, osteoarthritis, and others.
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